Sequestosome 1/p62 - More than just a scaffold

More than just vanilla.

More than just big ears

To the non-specialist, large ears in elephants used to mean African, small ears, Indian. But to taxonomists African elephants have long posed a more complex puzzle. During the nineteenth century, it was fashionable for wealthy trophy hunters to assign their own names to species they had shot destined for the museums of Europe. At least 18 elephant subspecies were claimed following this fashion....

AMPKβ subunits: more than just a scaffold in the formation of AMPK complex.

AMP-activated protein kinase (AMPK) is a sensor of energy status composed of a catalytic subunit (AMPKα), a scaffolding subunit (AMPKβ) and a regulatory subunit involved in nucleotide binding (AMPKγ). Activation of AMPK results in enhancement of catabolic processes and downregulation of anabolic pathways with the aim to equilibrate the energy status of the cell. The study of the regulation of t...

EHPnet: More Than Just Unleaded

Lipolysis: more than just a lipase

Successful adaptation to starvation in mammals depends heavily on the regulated mobilization of fatty acids from triacylglycerols stored in adipose tissue. Although it has long been recognized that cyclic AMP represents the critical second messenger and hormone-sensitive lipase (HSL)* the rate-determining enzyme for lipolysis, simple activation of the enzyme has failed to account for the robust...